Endocrine Abstracts

Introduction: Carney complex is a rare autosomal dominant genetic disorder which develops secondary to mutation in the PRKAR1A gene located in the 17q22-24 region. It is commonly characterised by the association between spotty skin pigmentation, cardiac myxoma and secretory endocrine tumors.Case presentation: A 15.8-year-old boy known with PRKAR1A mutation diagnosed based on his personal history – cutaneous papiloma of the neck resected at the age o...

Introduction: Cushing syndrome could be missed initially, especially when the presenting features are common in the general population. Before proceeding to the hormonal tests we have to consider that recent studies have shown that up to 50% of patients with CD have different degrees of altered glucose metabolism, up to 80% of CS patients have hypertension independently of their age and sex and hypercorticism changes bone structure and causes vertebral fractures in approximate...

Background: Dopamine agonists (DAs) were associated with valvular dysfunction in patients with Parkinson’s disease due to their fibrotic effect through the serotoninergic receptor. It is more difficult to prove the same effects in patients with prolactinoma due to the lower doses, variable doses and the longer follow-up period. Aim: To assess echocardiographic features in patients with prolactinoma under DA treatment.Methods: ...

Introduction: Medullary thyroid carcinoma (MTC) accounts for 3-9% of all thyroid cancers and only 0.7% develop paraneoplastic Cushing’s syndrome. However, incidence of endogenous Cushing’s syndrome is also low (1–3/million population/year), with a female preponderance, pituitary mediated ACTH production being responsible for up to 80% of these cases.Aim: To present the difficulties in the differential diagnosis of ACTH dependent hyperco...

BackgroundProlactinomas are the most frequent type of hormone-secreting pituitary adenomas. Prolactin(PRL)-receptor mediates intracellular signaling pathways that contribute to weight gain, dyslipidemia, impaired fasting glucose (IFG), type 2 diabetes mellitus (T2DM) and cardiovascular disease, parameters that improve along with PRL level control on dopamine agonist (DA) therapy.AimTo assess metabolic disturb...